解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Multigene-based combination therapy may be an effective practice in cancer gene therapy. Substantial studies have demonstrated that tumor suppressor p53 acetylation is indispensable for p53 activation. Inhibitor of growth 4 (ING4), as a novel tumor suppressor, is capable of remarkably enhancing p53 acetylation and its...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4385
更新日期:2016-01-01 00:00:00
abstract::Prostate and breast cancer overexpressed 1 (PBOV1) is significantly upregulated in prostate, breast and bladder cancer, while its expression status in ovarian cancer and its clinical significance are unclear. We examined the expression levels of PBOV1 mRNA and protein in ovarian cancer cell lines and primary tissues u...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4396
更新日期:2016-01-01 00:00:00
abstract::Colorectal cancer (CRC) is still one of the most important neoplasias causing human death. Multidisciplinary therapy has won consensus in the management of CRC, of which, radiotherapy occupies an important position. However, radioresistance is still a major obstacle in local control of CRC. Overexpression of long non-...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4397
更新日期:2016-01-01 00:00:00
abstract::Resolvins, an endogenous lipid mediator derived from eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) of fish oil, has been reported to have anti-inflammatory and antitumor effect in various pathogenic processes. However, there are no studies about the effects of resolvin D1 and E1 on concanavalin A-induced h...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4389
更新日期:2016-01-01 00:00:00
abstract::It is known that the TGF-β superfamily receptors act as master regulators of cancer progression. However, alteration and role of type III TGF-β receptor (TβRIII, or betaglycan) as the most abundant of the TGF-β receptor has not been explored in salivary gland adenoid cystic carcinoma (ACC). Here, we reported that tumo...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4390
更新日期:2016-01-01 00:00:00
abstract::X-ray-based radiotherapy is one of the most effective therapeutic strategies for breast cancer patients. However, radioresistance and side-effects continue to be the most challenging issues. B-cell translocation gene 1 (BTG1) is a member of the BTG/Tob family, which inhibits cancer growth and promotes apoptosis. We, t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4311
更新日期:2015-12-01 00:00:00
abstract::MicroRNA-154 (miR-154) has been identified as a tumor suppressor in several types of human cancers; however, its clinical significance and function in human hepatocellular carcinoma (HCC) remain unclear. The aim of the present study was to analyze the clinical significance and cellular function of miR-154 in HCC patie...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4321
更新日期:2015-12-01 00:00:00
abstract::The aims of the present study were to review the experience of different surgical reconstruction methods for hypopharyngeal squamous cell carcinoma (HSCC) and compared the survival of patients with and without laryngeal function (LF) preservation. The clinical characteristics of 580 patients were retrospectively obtai...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4313
更新日期:2015-12-01 00:00:00
abstract::Identification of novel botanicals that can selectively induce apoptosis and arrest growth of cancer cells without producing cytotoxic effects is highly appreciable for cancer therapy. The present study aimed to investigate the possibility of acetylbritannilactone (ABL) derivative 5-(5-(ethylperoxy)pentan-2-yl)-6-meth...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4293
更新日期:2015-12-01 00:00:00
abstract::Mitogenic actions of estrogens are mediated by two distinct estrogen receptors (ERs), which are critical in the progression and therapeutic response of breast cancer. ER expression is a dynamic phenomenon that is regulated by numerous factors, including cytokines, in the tumor microenvironment. Recently, studies have ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4294
更新日期:2015-12-01 00:00:00
abstract::Solid tumors are abnormal tissues containing tumor and non-tumor cells, also known as tumor stromal cells. However, the malignant potential of tumor stromal cells remains largely unknown. The aim of the present study was to investigate the malignant potential of host bone marrow‑derived stroma cells in transplanted su...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4281
更新日期:2015-12-01 00:00:00
abstract::To elucidate the molecular mechanisms underlying the pathogenesis and treatment of human primary hepatocellular carcinoma (HCC), it is important to explore novel HCC-associated genes. In the present study, we examined the expression of ubiquitin-specific peptidase 14 (USP14) in patients with HCC using quantitative PCR...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4296
更新日期:2015-12-01 00:00:00
abstract::Human telomerase reverse transcriptase (hTERT) plays an important role in the development of tumors and has been investigated as a potent target for anticancer therapy. In the present study, we constructed a recombinant adenovirus, Ad-EGFP-C197 which was capable of expressing COOH‑terminal polypeptide of hTERT (amino ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4298
更新日期:2015-12-01 00:00:00
abstract::Frizzled2 (Fzd2) is a receptor for wingless-type MMTV integration site family members (Wnts), the aberrant overexpression of which has been noted to contribute to cancer metastasis. The present study was performed to characterize the role of Fzd2 in the migration and invasion of oral squamous cell carcinomas (OSCC) in...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4285
更新日期:2015-12-01 00:00:00
abstract::OCT4B1, a splice variant of OCT4, is a key regulator in maintaining the properties of pluripotency and self-renewal in embryonic stem (ES) cells. Recent results have shown that OCT4B1 is involved in tumorigenesis. However, the contribution of OCT4B1 in the tumorigenesis and drug resistance of colon cancer remains to b...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4286
更新日期:2015-12-01 00:00:00
abstract::Autophagy is an intracellular multi-step catabolic degradation process that involves the degradation and recycling of cellular proteins and cytoplasmic damaged organelles to maintain cellular homeostasis and reduction of metabolic stress. Numerous studies have indicated the importance of autophagy in cancer, but the r...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4302
更新日期:2015-12-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is an aggressive disease with a poor outcome due to the high incidence of metastasis. Cancer stem cells (CSCs) have been identified to be responsible for tumor progression and may be generated by epithelial-mesenchymal transition (EMT) characteristics. CD133 is a specific surface marker ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4270
更新日期:2015-12-01 00:00:00
abstract::The model animal of renal cell carcinoma (RCC), the Eker rat, has a germline mutation in the tuberous sclerosis 2 (Tsc2) gene. Heterozygous mutants develop RCCs by second hit in the wild-type Tsc2 allele, whereas homozygous mutants are embryonic lethal. In the present study, a new cell differentiation model was develo...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4254
更新日期:2015-11-01 00:00:00
abstract::Investigations into extracellular vesicles (EVs) have significantly increased since their role in physiological and pathological processes has become more clearly understood. Furthermore, it has become increasingly clear that several subpopulations of EVs exist, such as exosomes (EXOs) and microvesicles (MVs). Various...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4199
更新日期:2015-11-01 00:00:00
abstract::Dendritic cells (DCs) as 'professional' antigen-presenting cells (APCs) initiate and regulate immune responses to various antigens. DC-based vaccines have become a promising modality in cancer immunotherapy. Cytokeratin 19 (CK19) protein is expressed at high levels in lung cancer and many other tumor cells, suggesting...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4231
更新日期:2015-11-01 00:00:00
abstract::Prostate cancer antigen 3 (PCA3) is a non-coding RNA fragment that is overexpressed in prostate cancer cells. However, the clinical applications of PCA3 are highly limited due to the instability of RNA and the lack of reliable and efficient RNA extraction and purification methods. Thus, in the present study, we compar...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4266
更新日期:2015-11-01 00:00:00
abstract::Hydrogen sulfide (H2S) participates in multifarious physiological and pathophysiologic progresses of cancer both in vitro and in vivo. We have previously demonstrated that exogenous H2S promoted liver cancer cells proliferation/anti‑apoptosis/angiogenesis/migration effects via amplifying the activation of NF-κB pathwa...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4248
更新日期:2015-11-01 00:00:00
abstract::Evidence has shown that microRNAs play important roles in tumor development, progression, and metastasis. miR-128 has been reported to be deregulated in different tumor types, whereas the function of miR-128 in colorectal carcinoma (CRC) largely remains to be elucidated. The aim of the present study was to investigate...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4251
更新日期:2015-11-01 00:00:00
abstract::Previous studies have demonstrated that the α5β1 integrin-mediated interaction with fibronectin (FN) occurs through the Arg-Gly-Asp (RGD) cell-binding sequence in repeat III10. Indocyanine green (ICG) is a near-infrared (NIR) optical dye that has been approved by the US Food and Drug Administration. In the present stu...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4142
更新日期:2015-10-01 00:00:00
abstract::MicroRNAs (miRNAs) play important roles in the the gene regulation of carcinogenesis including breast cancer. miR‑519d has been studied in various types of cancer, but its role in breast cancer remains unclear. In the present study, we investigated the expression and biological function of miR-519d in breast cancer. U...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4160
更新日期:2015-10-01 00:00:00
abstract::Emerging evidence suggests that cancer cells present profound epigenetic alterations in addition to featuring classic genetic mutations. Valproic acid (VPA), a histone deacetylase inhibitor, can potently inhibit tumor growth and induce differentiation. However, the effect and underlying mechanism of VPA on head and ne...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4145
更新日期:2015-10-01 00:00:00
abstract::Monoclonal antibody therapy for immune checkpoint blockade has achieved promising results for several types of malignant tumors. For the future treatment of gastrointestinal stromal tumors (GISTs) by immune checkpoint blockade, expression of immune checkpoint-related molecules that suppress antitumor immunity in GISTs...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4149
更新日期:2015-10-01 00:00:00
abstract::Ulcerative colitis (UC) is an important risk factor for colorectal cancer (CRC). Histone modifications are one of the epigenetic mechanisms that may have key roles in the carcinogenesis of CRC. At present, there are no studies comparing histone modification patterns of UC and CRC in the literature. Therefore the aim o...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4187
更新日期:2015-10-01 00:00:00
abstract::Gentian violet (GV) is a cationic triphenylmethane dye, with potent antifungal and antibacterial activity. We recently reported that in vitro GV suppresses the differentiation of bone resorbing osteoclasts while stimulating the differentiation and activity of bone forming osteoblasts. Breast cancer is highly metastati...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4190
更新日期:2015-10-01 00:00:00
abstract::Cisplatin, an important chemotherapeutic agent against testicular germ cell cancer, induces testicular toxicity on Leydig and Sertoli cells, leading to serious side-effects such as azoospermia and infertility. In a previous study, it was found that simvastatin enhanced the sensitivity of Leydig tumor cells to chemothe...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4192
更新日期:2015-10-01 00:00:00
abstract::Mother-to-infant transmission of hepatitis B virus (HBV) can occur as an intrauterine, intrapartum or postpartum infection. In the present study, we induced a multifunctional viral regulator of HBV gene products, HBx, and its different fragments to overexpress in a tropho-blast cell line, HTR-8/SVneo. We then identifi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4172
更新日期:2015-10-01 00:00:00
abstract::MicroRNA-374a (miR-374a) is involved in the progress of various types of cancer, and may indicate a poor prognosis. However, its role in esophageal cancer remains to be determined. In the present study, the role of miR-374a in esophageal cancers and cancer cell growth was examined using miR-374a overexpression and und...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4182
更新日期:2015-10-01 00:00:00
abstract::Graft-versus-host disease (GVHD) is a devastating complication of hematopoietic stem cell transplantation (HSCT), and is characterized by systemic inflammation and tissue damage in multiple organs, such as the liver and small intestine. Interleukin-18 (IL-18), an important pro-inflammatory cytokine, is elevated during...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4176
更新日期:2015-10-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are known to migrate to tumor tissues and to play an important role in cancer progression. However, the effects of MSCs on tumor progression remain controversial. The purpose of the present study was to detect the effects of human umbilical cord-derived MSCs (hUC‑MSCs) on the human breast...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4109
更新日期:2015-09-01 00:00:00
abstract::Novel agents need to be developed to overcome the limitations of the current melanoma therapeutics. Atractylenolide I (AT-I) is a sesquiterpene compound isolated from atractylodis macrocephalae rhizoma. Previous findings demonstrated that AT-I exhibited cytotoxic action in melanoma cells. However, the molecular mechan...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4111
更新日期:2015-09-01 00:00:00
abstract::With the ever-increasing number of drugs approved to treat cancers, selection of the optimal treatment regimen for an individual patient is challenging. Breast cancer complexity requires novel predictive methods and tools. In the present study, we set up experimental conditions to obtain an 'ex vivo' organotypic cultu...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4074
更新日期:2015-09-01 00:00:00
abstract::Lung cancer remains the leading cause of cancer-related mortality worldwide and non-small cell lung cancer (NSCLC) accounts for approximately 80-85% of all cases of lung cancer. Cisplatin plays a significant role in the management of human lung cancer. Translesion DNA synthesis (TLS) is involved in DNA damage repair. ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4121
更新日期:2015-09-01 00:00:00
abstract::Honokiol (HNK), a potential antitumor compound, has been widely studied in recent years. It induces apoptosis and affects autophagy in cancer cells, yet the mechanism of its antitumor efficacy remains obscure. Chloroquine (CQ), an autophagy inhibitor, is often applied to sensitize antitumor drugs in clinical trials. H...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4091
更新日期:2015-09-01 00:00:00
abstract::The WHO clearly identifies tumors as a curable or a chronic disease. The use of natural agents in cancer prevention and therapy is currently playing an important role. Our laboratory has been investigating various natural phenolic compounds, including grifolin, neoalbaconol and epigallocatechin-3-gallate (EGCG). In th...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.2015.4029
更新日期:2015-08-01 00:00:00
abstract::The presence of hypoxic regions within solid tumors is caused by an imbalance between cell proliferation and angiogenesis. Such regions may facilitate the onset of recurrence after radiation therapy and chemotherapy, as hypoxic cells show resistance to these treatments. We found that tempol, a nitroxide, strongly indu...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4020
更新日期:2015-08-01 00:00:00